View source for Magnesium tests with AGiR!

Following [http://wiki.hackuarium.ch/w/20180418_OH198 the presentation by Bérnard Dugas on the work of Pierre Delbet (18apr18)], controlled tests of topical application of MgCl2 are proposed.

Formulations need final ok, and participants are needed... <br>
Certainly, Mg++ is essential in active sites of both enzymes ([http://www.genomicintegrity.org/ with inspiration via AGiR!]) and *ribozymes*... <br>
Another reason magnesium should be of clear interest to everyone also has to do with the fact that ATP (our cells' energy) is not used simply, just as itself - it is used as Mg-ATP. Stability of nucleic acids & activity more than 300 enzymes are absolutely dependent on magnesium. [https://en.wikipedia.org/wiki/Magnesium_in_biology This wikipedia page] has more fun facts...<br>

Here are a few interesting and relatively recent articles related to the effects of magnesium on health: <br>

Association between magnesium intake and risk of colorectal cancer among postmenopausal women. <br>[https://www.ncbi.nlm.nih.gov/pubmed/26390877 Gorczyca AM et al. Cancer Causes Control. (2015)]<br>
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Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study. <br>[https://www.ncbi.nlm.nih.gov/pubmed/26554653 Dibaba D et al. Br J Cancer. (2015)]<br>
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Dietary magnesium intake and risk of cancer: a meta-analysis of epidemiologic studies. <br>[https://www.ncbi.nlm.nih.gov/pubmed/24910891 Ko HJ et al. Nutr Cancer. (2014)]<br>
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However, Delbet's work (pdf available from the OH198 page, linked above) indicates also that topical applications can help everything from healing wounds to restoring hair pigmentation! <br>
Could this be true??  <br>

There is a more recent attempt (2017) to pull current data together in this regard (transdermal applications).  <br>
Furthermore, there is a great quote from the article: ''Scepticism based on ignorance impairs scientific evaluation as much as claims based on excessive faith.'' <br>
However, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579607/ their synthesis] in the end (while including citations totally supporting the oral route for using magnesium to benefit health) does not support the idea that transdermal application would be effective. <br>
Still, a good bath reduces stress... :)  
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So, if we do try for a participative research study in this regard, it seems most likely the simple MgCl taken orally will be most interesting. <br>
Are you interested!?<br>
Want to help co-design another study in this regard??
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Contact rachel (at) hackuarium (dot) ch if you are keen to join in! <br>
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 [[File:CoverDelbet.jpg]]